健脾清肠汤治疗脾虚湿热型溃疡性结肠炎40例

JianPi QingChang Decoction in Treating 40 Cases of Ulcerative Colitis of Spleen-deficiency Damp-heat Pattern

目的:观察健脾清肠汤治疗脾虚湿热型溃疡性结肠炎的临床疗效。方法:将80例患者随机分为观察组、对照组各40例,对照组行对症支持处理,观察组在对照组治疗的基础上服用健脾清肠汤,每日1剂。2组均连续治疗1个月。观察2组临床症状改善时间、炎症相关因子水平及Truelove分级情况。结果:腹痛腹胀、腹泻、便血及里急后重改善时间观察组均早于对照组,差异有统计学意义(P<0.05)。肿瘤坏死因子α(TNF-α)、白介素6(IL-6)、超敏C反应蛋白(hs-CRP)水平干预后观察组均低于对照组,差异有统计学意义(P<0.05)。肠镜复查Truelove分级中Ⅱ级及以下者干预后观察组37例(92.5%),对照组29例(72.5%),2组比较差异有统计学意义(P<0.05)。结论:健脾清肠汤治疗慢性溃疡性结肠炎,能较快的缓解患者临床症状,减轻机体炎症反应,提高临床治疗效果。

Objective: To observe therapeutic effects of Jian Pi Qing Chang decoction in treating ulcerative colitis(UC). Methods: Eighty patients were randomized into the observation group and the control group, 40 cases each group, the control group accepted symptomatic treatment, and the observation group took Jian Pi Qing Chang decoction on the foundation of the treatment the control group received, one dose each day. Both groups were treated for one month consecutively. Truelove classification conditions, the levels of inflammatory factors and the improving time of clinical symptoms of both groups were observed. Results: The observation group was earlier than the control group in the improving time of abdominal pain, abdominal distension, diarrhea, hematochezia and tenesmus, and the difference showed statistical meaning(P <0.05). The observation group was lower than the control group in the levels of TNF-α, IL-6 and hs-CRP, and the difference was statistically significant(P<0.05). There were 37 cases(92.5%) in the observation group and 29 cases(72.5%) in the control group of grade Ⅱ amd lower than grade Ⅱ after the intervention according to Truelove classification, and the difference showed statistical meaning(P<0.05). Conclusion:Jian Pi Qing Chang decoction in treating UC patients could relieve clinical symptoms rapidly, alleviate inflammatory reaction of the body and improve clinical therapeutic effects.