高剂量奥美拉唑四联疗法治疗幽门螺杆菌性胃炎患者疗效观察

Efficacy of high dose omeprazole quadruple therapy in the treatment of Helicobacter pylori gastritis

目的观察高剂量奥美拉唑四联疗法治疗幽门螺杆菌性胃炎患者的临床效果。方法选取幽门螺杆菌性胃炎患者114例,采用随机数字表法分为对照组和观察组,每组57例。对照组患者采用常规剂量奥美拉唑四联疗法治疗;观察组患者采用高剂量奥美拉唑四联疗法治疗,疗程2周。比较两组患者的临床治疗效果、治疗前后症状积分及不良反应发生情况。结果观察组患者的治疗总有效率为87.72%,对照组为70.18%,观察组患者的临床疗效显著优于对照组,差异有统计学意义(P<0.05)。治疗前,两组患者症状积分比较差异无统计学意义(P>0.05);治疗后,两组患者症状积分均明显下降,观察组患者症状积分显著低于对照组,差异有统计学意义(P<0.05)。治疗过程中两组患者中均仅有少量患者出现轻微的头晕头痛、腹泻、恶心、呕吐等不良反应。结论采用高剂量奥美拉唑四联疗法治疗幽门螺杆菌性胃炎患者临床疗效显著,能有效缓解患者的临床症状,不会增加患者的不良反应,治疗安全性较高。

ObjectiveTo observe the clinical effect of high-dose omeprazole quadruple therapy in the treatment of Helicobacter pylori gastritis. Methods114 cases of Helicobacter pylori gastritis were selected and divided into the control group and the observation group by the random digital table method, with 57 cases in each group. The control group were treated with the conventional dose of omeprazole, and the observation group were treated with high-dose omeprazole quadruple therapy. The two groups were treated for 2 weeks. The clinical effect, the symptom score before and after the treatment and the occurrence of adverse reaction were compared between the two groups. ResultsThe total effective rate of treatment was 87.72% in the observation group and 70.18% in the control group. The clinical efficacy of the observation group was significantly better than that of the control group, and the difference was statistically significant （P〈0.05）. There was no significant difference in the symptom score of the two groups before treatment, （P〉0.05）. The symptom scores of the two groups were obviously decreased, and the symptom scores of the observation group were significantly lower than those in the control group after treatment, the difference was statistically significant （P〈0.05）. In the course of treatment, there were a few patients with slight dizziness, headache, diarrhea, nausea, vomiting and other adverse reactions in the two groups of patients. ConclusionThe clinical efficacy of high dose omeprazole quadruple therapy is significant in the treatment of Helicobacter pylori gastritis. It can effectively relieve the clinical symptoms of the patients, and will not increase the adverse reaction of the patients.