肺癌患者癌因性疲乏的原因或影响因素及其对患者生活质量的影响

The causes or influence factors of carcinomatous fatigue in patients with lung neoplasms and the influence of carcinomatous fatigue on the quality of life of the patients

目的探讨肺癌患者癌因性疲乏(CRF)的原因或影响因素,分析癌因性疲乏对患者生活质量的影响。方法选取2013年9月至2016年12月在我院接受治疗的肺癌患者156例为研究对象,入院后采用癌症疲乏量表及生命质量测评量表对患者进行评估,对接受化疗的患者于化疗第7天再次进行评估。结果 156例患者中108例患者出现了疲乏,疲乏发生率为69.3%,中度疲乏患者的比例最高,患者PFS量表平均得分为(5.56±2.44)分。多因素Logistic回归分析结果显示,血红蛋白、血清白蛋白水平是肺癌患者发生癌因性疲乏的危险因素。肺癌患者化疗后的疲乏评分显著高于化疗前(P<0.05),疲乏发生率显著高于化疗前(P<0.05)。Pearson相关分析结果显示,肺癌患者癌因性疲乏评分与患者的生存质量评分呈负相关(P<0.05)。结论低血红蛋白血症、低白蛋白血症、化疗与肺癌患者发生癌因性疲乏有关,癌因性疲乏会严重影响患者的身心健康,临床上必须给予足够的重视。

ObjectiveTo analysis of the causes or influencing factors of carcinomatous fatigue （CRF） in patients with lung neoplasms and the influence of CRF on the quality of life of the patients. Methods156 cases of lung neoplasms patients who were treated in our hospital from September 2013 to December 2016 were selected, which were evaluated by the cancer fatigue scale and the quality of life assessment scale after admission. The patients receiving chemotherapy were evaluated again for seventh days of chemotherapy. Results108 cases were tired of the 156 patients. The incidence of fatigue was 69.3%. The highest proportion of patients with moderate fatigue. The average score of the patient′s PFS scale was （5.56±2.44） points. The results of multiple factor Logistic regression analysis showed that, hemoglobin and serum albumin levels are risk factors for carcinonic fatigue in patients with lung neoplasms. The fatigue score of lung neoplasms patients after chemotherapy was significantly higher than that before chemotherapy （P〈0.05）. The incidence of fatigue was significantly higher than that before chemotherapy （P〈0.05）. The results of Pearson correlation analysis show that, there was a negative correlation between the carcinomatous fatiguescore and the quality of life score of the patients with lung neoplasms （P〈0.05）. ConclusionHypohemoglobin, hypoalbuminemia, chemotherapy and carcinomatous fatigue in patients with lung neoplasms. Carcinomatous fatigue can seriously affect the physical and mental health of the patients. Attention should be given to the treatment.