单用酚妥拉明与联合垂体后叶素治疗支气管扩张咯血Meta分析

Phentolamine alone or uniting pituitrin in the treatment of bronchiectasis hemoptysis: a Meta-analysis

目的研究单独应用酚妥拉明与联合垂体后叶素治疗支气管扩张咯血的疗效评价。方法计算机检索Pub Med、Elsevier、Wiley、万方数字化期刊、中国期刊全文数据库及维普中文科技期刊数据库中有关单用酚妥拉明与联合垂体后叶素治疗支气管扩张咯血的临床随机对照研究,检索时间为2005年1月至2017年9月,采用Rev Man5.3软件进行Meta分析,比较单用酚妥拉明与联合垂体后叶素的有效性及安全性。结果本研究共纳入5篇文献,共计388例患者。与单用酚妥拉明治疗比较,酚妥拉明联合垂体后叶素治疗支气管扩张咯血的显效率(OR合并=1.69,95%可信区间1.10~2.61,P<0.05)及总有效率更高(OR合并=5.09,95%可信区间2.47~10.49,P<0.01),无效率(OR合并=0.20,95%可信区间0.10~0.40,P<0.01)及不良反应发生率更低(OR合并=0.38,95%可信区间0.19~0.75,P<0.01)。结论酚妥拉明联合垂体后叶素治疗支气管扩张咯血的效果更加显著,安全性更高。

Objective To compare the effects between using phentolamine alone and uniting the pitutrin in bronchiectasis with massive hemoptysis. Methods Searching Pub Med,Elsevier,Wiley,Wangfang digital journal,CNKI and Weipu Chinese technology journal for the articles related with bronchiectasis with massive hemoptysis treated by phentolamine and pituitrin in English and Chinese databases. Using Rev Man 5. 3 software to meta-analyze,and compare the effects and safety of using phentolamine alone and uniting the pitutrin from January 2005 to September 2017. Results Five randomized controlled trials were selected,including 388 patients. The marked effective rate（ ORcom= 1. 69,95% CI： 1. 10-2. 61,P 〈 0. 05） and total effective rate of phentolamine uniting pituitrin was higher（ ORcom= 5. 09,95% CI： 2. 47-10. 49,P 〈 0. 01）. The inefficiency of drug combination was lower（ ORcom= 0. 20,95% CI： 0. 10-0. 40,P 〈 0. 01）. Using them together has lesser side effects（ ORcom= 0. 38,95% CI： 0. 19-0. 75,P 〈 0. 01）. Conclusion The effects of using phentolamine uniting pituitrin in bronchiectasis with massive hemoptysis has a great curative effect.