摘要
目的:调查某三甲医院住院患者使用注射用亚胺培南/西司他丁后发生肝功能异常的病例,为提高该药用药安全性提供依据。方法:调取该院2016年2月~2017年1月使用亚胺培南/西司他丁住院患者病历1 372份,对患者基本信息、药物使用情况及用药期间肝功能指标等进行统计分析。结果:1 372例静滴正常剂量亚胺培南/西司他丁的患者连续给药(6.29±3.99)d后,28例患者发生肝功能异常[AST(102.96±43.74)U·L^(-1),ALT(131.79±74.03)U·L^(-1)],发生率为2.04%;停用亚胺培南/西司他丁5~6 d后患者肝功能基本恢复正常;用药期间患者血清胆红素含量均在正常水平。结论:亚胺培南/西司他丁导致的肝功能异常为常见急性肝细胞损伤型药物性肝损伤,其损伤程度较轻且可逆,但依然应引起医生和药师关注。
Objective：To investigate the inpatients of liver dysfunction induced by imipenem cilastin for promoting the rational use of it.Methods：The inpatients cases using imipenem cilastin from February 2016 to January 2017 were gathered, and the basic information, drug use and liver function of inpatients were statistic analyzed. Results：1 372 inpatients were intravenously dripped imipenem cilastin for （6.29±3.99）d, 28 inpatients occurred liver dysfunction [AST （102.96±43.74）U·L^-1, ALT （131.79±74.03）U·L^-1]. The incidence rate was 2.04%. The liver function was recovered after stop using imipenem cilastin 5 6d. While, the levels of serum bilirubin were normal during the administration.Conclusion：The liver dysfunction induced by imipenem cilastin was acute liver cell damage type of drug induced liver injury, which was reversible and slight. However, doctor and pharmacist should pay attention.
出处
《药物流行病学杂志》
CAS
2018年第1期38-41,共4页
Chinese Journal of Pharmacoepidemiology
基金
国家自然科学基金项目(编号:81403170)
