芬吗通不同给药方式对改善子宫内膜厚度及妊娠情况临床研究

Clinical study of different ways of administration of femoston to improve endometrial thickness and pregnancy

目的:分析并探讨芬吗通不同给药方式对改善子宫内膜厚度及妊娠的临床效果影响,从而选择合适的给药方式进行治疗。方法:选取2014年1月至2016年1月在医院接受治疗的薄型子宫内膜不孕者200例为研究对象,随机分为观察组与对照组,各100例。观察组口服和阴道给药芬吗通,对照组仅口服药物。结果:两组治疗后子宫内膜厚度均明显增厚,观察组增加更加明显,差异有统计学意义(P<0.05)。两组治疗后E2水平明显升高,观察组升高更加明显,差异有统计学意义(P<0.05)。观察组妊娠率为58.00%,早期流产发生率为5.17%。对照组妊娠率为36.00%,早期流产发生率为25.00%。观察组妊娠率明显高于对照组,且早期流产率低于对照组(P<0.05)。结论:口服联合阴道给药芬吗通可以有效的改善子宫内膜厚度,且妊娠率高,临床上值得推广。

Objectives： To analyze and explore the effect of different administration ways of femoston on improving endometrium function,to choose the appropriate way of treatment. Methods： From January 2014 to January 2016,200 infertile women with thin endometrial infertility treated in our hospital were randomly divided into observation group and control group,with 100 cases in each group. Observation group was given oral administration and vaginal administration of femoston. Control group was given oral administration of femoston only. Results： The thickness of endometrium was significantly thickened after treatment in the two groups,and the observation group increased more significantly（ P〈0. 05）. The levels of estrogen E2 in the two groups were significantly increased,and observation group was significantly higher than those in control group（ P〈0. 05）. The pregnancy rate of observation group was 58. 00%,and the incidence of early abortion was 5. 17%. The pregnancy rate of control group was 36. 00%,and the incidence of early abortion was 25. 00%. The pregnancy rate of observation group was significantly higher than that of control group,and early abortion rate of observation group was lower than that of control group（ P〈0. 05）. Conclusion： Oral administration combined with vaginal administration of femoston can effectively improve the thickness of endometrium,with high pregnancy rate,which is worthy of promotion in clinical practice.