行为疗法联合普拉克索对早发型帕金森病合并抑郁症患者HAMD评分、Zung评分和UPDRS Ⅱ、Ⅲ评分的影响

The Influence of Behavior Therapy Combined with Pramipexole on HAMD Score,Zung Score and UPDRS Ⅱ and Ⅲ Scores in the Treatment of Patients with Early-onset Parkinson’s Disease and Depression

目的：探讨行为疗法联合普拉克索对早发型帕金森病合并抑郁症患者汉密尔顿抑郁量表（HAMD）评分、Zung评分和帕金森综合评分量表（UPDRS）Ⅱ、Ⅲ评分的影响。方法：选择2015年2月-2016年11月于我院就诊的早发型帕金森病合并抑郁症患者共94例,随机分为联合组和对照组,对照组给予普拉克索治疗,联合组在普拉克索的基础上联合行为疗法,对比两组患者治疗前后的HAMD评分、Zung评分和UPDRS Ⅱ、Ⅲ评分。结果：两组患者的Hoehn-Yahr评分和改良Webster评分比较差异无统计学意义,两组患者治疗前的HAMD和Zung评分比较差异无统计学意义,治疗1个月和治疗3个月联合组的HAMD和Zung评分显著低于对照组,差异具有统计学意义（t=-6.666,-12.615,-3.321,-5.319;P〈0.001）,两组患者治疗前的UPDRS Ⅱ和UPDRS Ⅲ评分比较差异无统计学意义（t=-0.175,P=0.861;t=0.263,P=0.793）,治疗1个月和治疗3个月联合组的UPDRS Ⅱ和UPDRS Ⅲ评分显著低于对照组,差异具有统计学意义（t=-9.718,-4.887,-3.188,-4.549;P〈0.001）。结论：行为疗法联合普拉克索能显著改善早发型帕金森病合并抑郁症患者的HAMD评分、Zung评分和UPDRS Ⅱ、Ⅲ评分,以促进其抑郁症状的改善和日常活动能力的提高。

Objective：To study the influence of behavior therapy combined with pramipexole in the treatment of patients with early-onset Parkinson’s disease and depression with HAMD scores,Zung score and UPDRS Ⅱ and Ⅲ score.Methods：From February 2015 to November 2016,a total of 94 cases with early-onset Parkinson’s disease and depression were selected in our hospital,which were randomly divided into the combined group and the control group.The control group were given pramipexole treatment,and the combined group using the behavior therapy combined with pramipexole,the HAMD scores,Zung score and UPDRS Ⅱ and Ⅲ score were compared between the two groups of patients before and after treatment.Results：Two groups of patients’ Hoehn-Yahr score and improvement Webster score had no significant difference,the HAMD and Zung scores of two groups of patients before treatment had no significant difference.1 month and 3 months after treatment,HAMD and Zung scores in the combined group were significantly lower than those in the control group（t=6.666,2.615,-3.321,-5.319;P〈0.001）.The UPDRS Ⅱ and UPDRS Ⅲ scores of two groups of patients had no significant difference before treatment;1 month and 3 months after treatment,UPDRS Ⅱ and UPDRS Ⅲ scores were significantly lower in the combined group than that in the control group（t=-9.718,-4.887,-3.188,-4.549;P 〈0.001）.Conclusion：Behavior therapy combined with pramipexole can significantly improve the patients with early-onset Parkinson’s disease and depression’s HAMD score,Zung score and UPDRS Ⅱ,Ⅲ grade,which also can relief its depressive symptoms and improve the daily activity ability.