远端胃癌根治术术后复发转移与硫氧化还原蛋白-1 表达的关系

Relationship between Recurrence and Metastasis and Expression of Thioredoxin -1 after RadicalResection of Distal Gastric Cancer

【目的】探讨远端胃癌根治术后复发转移与硫氧化还原蛋白-1（Trx-1）表达的关系。【方法】本院行远端胃癌根治术患者手术切除标本139例，其中复发转移患者62例（复发组），无复发转移77例（无复发组），采用免疫组织化学染色检测其Trx-1表达水平，并分析Trx-1表达与远端胃癌根治术术后复发转移的关系。【结果】复发组患者组织中Trx-1阳性表达率为（87．10±8．72）％，高于未复发患者组织中阳性表达率（25．58±10．25）％，和正常组织（10．25±3．14）％，且差异均具有显著性（P〈0．05）。而正常组织中与未复发患者组织中Trx-1阳性表达率相比较差异无显著性（P〉0．05）。62例复发患者中Trx-1高表达组术后中位无病生存期为（13．5±2．84）个月，显著短于Trx-1低表达组术后中位无病生存期（18．6±3．58）个月。多因素Cox模型显示Trx-1高表达、TNM分期、肿瘤大小和淋巴结转移是影响胃癌患者无病生存的独立因素。【结论】Trx-1表达水平升高与远端胃癌根治术后无病生存时间缩短有关。

[Objective]To investigate the relationship between recurrence and metastasis and the expres- sion of thioredoxin 1 （Trx-1） after radical resection of distal gastric cancer. [Methods]A total of 139 patients who underwent radical resection of distal gastric cancer in our hospital were collected in the study. It included 62 cases of recurrence and metastasis （recurrence group） and 77 cases of non recurrence and metastasis （non- recurrence group）.. The expression of Trx-1 was detected by immunohistochemical staining, and its relation- ship with recurrence and metastasis after radical resection of distal gastric cancer was analyzed. [Results]The positive expression rate of Trx-1 in the tissues of recurrence patients （87.10±8.72）% was significantly higher than those in the tissues of non-recurrence patients and normal tissues E（25.58±10.25） % and （10.25±3.14） %]（ P 〈0.05）. There was no significant difference in the positive rate of Trx-1 between normal and non- recurrent patients （ P 〈0.05）. Among 62 recurrent cases, the median disease-free survival time of patients with high expression was （13.5±2.84） months, which was shorted than that of patients with low expression with （18.6 ± 3.58） months. Multivariate Cox model showed that high expression of Trx-1, TNM stages, tumor size and lymph node metastasis were the independent {actors for the disease-free survival of patients with gastric cancer. [Conclusion] The increased expression of Trx-1 is associated with the shortening of dis- ease-free survival time after radical resection of distal gastric cancer. Trx-1 can be used as a marker for predic- ting recurrence and metastasis of distal gastric cancer after radical resection.