匹诺塞林的神经保护作用机制研究进展

Recent Progress in Understanding the Mechanism of Neuroprotective Effect of Pinocembrin

匹诺塞林(pinocembrin)化学名为5,7-二羟基黄烷酮,是从蜂蜜,蜂胶,姜,野生马郁兰等提取的一种黄酮类化合物,具有抗氧化、抗炎、血管舒张等多方面的作用。其在体内外具有广泛的神经保护作用。笔者就匹诺塞林在脑缺血和神经退行性疾病中的神经保护作用进行了综述,总结了其在动物及细胞实验水平的药理学活性、可能的神经保护作用机制。

Pinoeembfin （5, 7-dihydroxyflavanone） , a flavanone, is a natural flavonoid compound extracted from honey, propolis, ginger roots, wild marjoram, and other plants. In preclinical studies, it has shown to have neuroproteetive effects as well as the ability to reduce reactive oxygen species, protect the blood-brain barrier, modulate mitoehondrial function, and regulate apoptosis. Considering these a variety of pharmacological activities, pinocembrin has potential as a drug to treat isehemic stroke and neurodegenerative disease. Its pharmacologic characteristics are summarized and mechanistic details relating preclinical studies are discusses.