基于中医五行音乐背景的rTMS治疗脑梗死后抑郁症的临床疗效观察

Therapeutic effect of r TMS on depression after cerebral infarction based on the five elements of Chinese music background

目的观察以中医五行音乐为背景采用重复经颅磁刺激(rTMS)治疗脑梗死后抑郁症的临床疗效。方法将120例脑梗死后抑郁患者按照随机数字表法分为两组,观察组60例以中医五行音乐为背景采用rTMS治疗,对照组60例采用氟西汀肠溶片治疗,共治疗8周。分别于治疗前后对两组患者的汉密尔顿抑郁量表(HAMD)评分、Zung抑郁自评量表(SDS)评分、生活质量指数(Barthel)评分、抑郁症相关因子(5-HT、OFQ)水平进行测定,评价临床疗效。结果治疗前,两组患者各项指标比较差异无统计学意义(P>0.05)。治疗后,两组患者的HAMD,SDS和Barthel积分,抑郁症相关因子(5-HT,OFQ)水平比治疗前均有明显改善(P<0.05),且观察组改善程度优于对照组(P<0.05)。观察组总有效率(90.0%)优于对照组总有效率(78.3%)。结论以中医五行音乐为背景采用重复经颅磁刺激(rTMS)治疗脑梗死后抑郁症的临床疗效显著,可明显改善抑郁量表的评分,降低抑郁相关因子5-HT与OFQ水平,提高患者生活质量,促进患者康复的配合度,加快患者回归社会的速度。

Objective To observe the clinical efficacy of using repetitive transcranial magnetic stimulation（ rTMS） in the treatment of depression after cerebral infarction on the background of the five elements of Chinese medicine. Methods The 120 patients with depression after cerebral infarction were divided into two groups according to the random number table. 60 patients in the observation group were treated with rTMS in the music of the Five Elements of TCM,and 60 patients in the control group were treated with fluoxetine enteric-coated tablets for 8 weeks. The Hamilton Depression Rating Scale（ HAMD）,the Zung Depression Self-rating Scale（ SDS）,the Barthel score,and the depression-related factor（ 5-HT,OFQ） were measured before and after treatment Measurement,evaluation of its clinical efficacy. Results Before treatment,there was no significant difference between the two groups（ P〈0. 05）. After treatment,HAMD,SDS and Barthel scores,5-HT and OFQ levels in both groups were significantly improved（ P〈0. 05）,and the improvement in the observation group was better than that in the control group 0. 05）. The total effective rate of observation group 90. 0% is better than that of control group 78. 3%. Conclusion The clinical efficacy of repetitive transcranial magnetic stimulation（ rTMS） in the treatment of depression after cerebral infarction was significantly improved on the background of the five elements of traditional Chinese medicine（ TCM）. It could significantly improve the scale of depression scale,reduce the level of 5-HT and OFQ,and improve the quality of life of patients,To promote the degree of patient rehabilitation,speed up the return of patients to society.