骨髓间充质干细胞移植治疗糖尿病及其并发症的现状及研究进展

Current situation and research progress of BMSCs transplantation in the treatment of diabetes mellitus and diabetes complications

骨髓间充质干细胞(BMSCs)具有很强的自我更新能力和多向分化潜能,是细胞移植的理想细胞,在临床上广泛用于治疗糖尿病、骨关节病等。BMSCs通过增加患者体内胰岛素和C-P水平,使患者不依赖外源性胰岛素即可良好地控制血糖。近年来,多项研究证实了BMSCs移植治疗糖尿病的安全性及有效性。BMSCs移植治疗糖尿病肾脏疾病(DKD)、糖尿病周围血管病、糖尿病心肌病、糖尿病骨病等并发症也取得了良好的效果。然而,由于缺乏标准化的移植方案,BMSCs移植在临床上应用受到了限制。本文通过回顾文献,总结了BMSCs移植在治疗糖尿病及其并发症的现状和研究进展。

Bone marrow mesenchymal stem cells （BMSCs） have a strong self-renewal ability and multi-directional differentiation potential, so they are ideal cells for cell transplantation, and are widely used in the treatment of diabetes,osteoarthritis and other diseases. BMSCs could increase insulin and C peptide levels in patients by a variety of mechanisms, and a good blood glucose control could be achieved without exogenous insulin therapy. Recently,a number of clinical studies confirmed the safety and effectiveness of BMSCs transplantation in the treatment of diabetes. BMSCs transplantation has also achieved good results for treating complications of diabetes, such as diabetic nephropathy, diabetic peripheral vascular disease, diabetic cardiomyopathy, diabetic bone disease and others. However, due to the lack of standardized transplantation regimens, BMSCs transplantation has been limited in the clinical application. This review summarized the status and research progress of BMSCs transplantation in the treatment of diahetes mellitus and its complications.