D-二聚体联合癌胚抗原在非小细胞肺癌远处转移诊断及预后评估中的应用

Application of D-dimer combined with carcinoembryonicantigen in diagnosis of metastasis and evaluation of prognosis of patients with non-small-cell lung cancer

目的研究D-二聚体联合癌胚抗原(CEA)在非小细胞肺癌(NSCLC)远处转移诊断及预后评估中的应用价值。方法选取2011年1月至2016年1月期间我科收治的140例NSCLC病人作为研究对象,比较不同临床资料病人的D-二聚体及CEA水平,比较D-二聚体、CEA及二者联合在远处转移中的诊断价值。采用COX回归分析病人预后的相关因素。结果 D-二聚体诊断NSCLC远处转移的灵敏度为70.69%,特异度为90.24%,曲线下面积(AUC)为0.635;CEA的灵敏度为81.03%,特异度为86.59%,AUC为0.624;D-二聚体联合CEA的灵敏度为87.93%,特异度为85.37%,AUC为0.704。病理分期、远处转移、D-二聚体水平与NSCLC病人的预后有显著相关性(P<0.05)。结论 D-二聚体联合CEA在NSCLC远处转移的诊断及病人的预后评估中具有应用价值。

Objective To study the value of combined detection of D-dimer and carcinoembryonicantigen（CEA） in the evaluation of prognosis and diagnosis of metastasis in the patients with non-small-cell lung cancer（NSCLC）.Methods From January 2011 to January 2016,140 patients with NSCLC were enrolled in this study.The sensitivity,specificity and area under curve（AUC）of D-dimer,CEA and combined detection were compared.The relative factors of prognosis of patients were analyzed.Results The sensitivity,specificity and AUC of D-dimer in the diagnosis of metastaasis were 70.69%,90.24%,0.635,respectively; compared with 81.03%,86.59% and 0.624 of CEA;compared with 87.93%,85.37% and 0.704 of combined detection of D-dimer and CEA.Tumor stage,metastasis,D-dimer and CEA were significantly associated with prognosis of the patients with NSCLC（P0.05）.Conclusions D-dimer combined with CEA shows applicative value in the evaluation of prognosis of NSCLC patients.