肠道菌群及其代谢产物与肥胖的关系

Relationship between gut microbiota,its metabolites and obesity

研究发现,肠道菌群参与肥胖的发病过程,且作为肠道菌群的重要代谢产物：短链脂肪酸、脂多糖、甲烷、氧化三甲胺等,通过提高对能量物质的获取,引起机体的慢性炎性反应,减慢肠道蠕动以提高吸收效率,造成胆固醇在细胞内的堆积,从而诱导肥胖、胰岛素抵抗,促进动脉粥样硬化斑块的形成.

Studies have found that gut microbiota played an indispensable role in the pathogenesis of obesity.And as important metabolites of gut microbiota：short chain fatty acids,lipopolysaccharides,methane,trimethylamine etc,can increase the acquisition of energy material,cause chronic inflammation of the body,slow the intestinal peristalsis to promote the absorption efficiency,result in the accumulation of cholesterol in the cells,thereby induce obesity,insulin resistance,and promote the accumulation of atherosclerotic plaques formation.