摘要
血清颗粒蛋白前体（PGRN）是一种脂肪因子,与急慢性炎性反应、肿瘤、组织损伤修复有关.近年来发现,PGRN还参与糖尿病的发生,在糖尿病患者体内表达增加.PGRN可以通过白细胞介素-6炎性通路抑制胰岛素信号通路,促进胰岛素抵抗的发生.最近的研究表明,血清PGRN会随着糖尿病视网膜病变的进展而升高,而血清和尿PGRN与糖尿病肾病进展也密切相关,提示PGRN有望成为监测糖尿病微血管病变病情变化的一项指标.
Serum progranulin,known as an adipocyte factor,is related to acute and chronic inflammations,tumors,wound repair.In recent years,progranulin is found to be related to diabetes,the concentrations of serm progranulin is high in diabetic patients.Progranulin participates in insulin resistance through interlukin-6 inflammatory pathway.Recent studies have found that serum progranulin is elevated with the progress of diabetic retinopathy.Serum and urinary progranulin is also related to the progress of diabetic nephropathy,which indicates progranulin is expected to be a marker of monitoring the progression of diabetic microvasular complications.
出处
《国际内分泌代谢杂志》
2018年第1期44-47,共4页
International Journal of Endocrinology and Metabolism
基金
无锡市科技发展计划项目（CSE31N1614,CSE01011）
无锡市医管中心面上项目（YG-ZXMl406）
无锡市医管中心联合攻关项目（YGZXL1322）
