Semaphorin3A及其受体与糖尿病血管并发症的关系

Relationship between Semaphorin3A, its receptors and diabetic vascular complications

Semaphorin3A是最初在神经系统中发现的分泌型糖蛋白.它有两个受体：Nrp和Plexin.Nrp为非酪氨酸激酶跨膜糖蛋白,Plexin为单通道跨膜蛋白家族成员.近年来发现,Semaphorin3A及其受体可介导内皮细胞受损,与糖尿病肾病、糖尿病视网膜病变、糖尿病神经病变等并发症密切相关,促进糖尿病血管并发症的发生与发展.对Semaphorin3A更深入的研究,将为糖尿病血管并发症的早期诊断、监测和治疗开辟新的途径.

Semaphorin3A is a secretory glycoprotein originally found in the nervous system.Its has two receptors：Nrp and Plexin.Nrp is a non-tyrosine kinase transmembrane glycoprotein and Plexin is a member of single-channel transmembrane protein family.In recent years,it has been found that Semaphorin3A and its receptors can mediate the damage of endothelial cells and are closely related to the complications such as diabetic nephropathy,diabetic retinopathy and diabetic neuropathy,and promote the occurrence and development of diabetic vascular complications.Along with more and more researches of Semaphorin3A,new pathways for early diagnosis,monitor and intervention of diabetic vascular disease would be found.