细胞因子与妊娠糖尿病的关系

Relationship between cytokines and gestational diabetes mellitus

妊娠糖尿病（GDM）的发病机制尚未明确,可能与胰岛素抵抗（IR）和胰岛β细胞功能受损有关.研究发现,胎球蛋白A、脂肪酸结合蛋白4、成纤维细胞生长因子21可能通过影响胰岛素信号通路,改变胰岛素敏感性;视黄醇结合蛋白4通过炎性反应机制导致IR;Wnt诱导分泌蛋白-1、分泌型卷曲相关蛋白5则作用于Wnt信号通路,参与调节炎性反应;鸢尾素可促进脂肪细胞燃烧;促代谢因子通过调节血脂代谢间接调节血糖.总之,细胞因子作用机制复杂,其分泌紊乱与GDM的发生、发展密切相关.

The pathophysiology of gestational diabetes mellitus（GDM） remains incompletely understood,insulin resistance and islet β cells dysfunction may involved in the pathogenesis of GDM.Studies indicated that fetuin A,fibroblast growth factor 21 and fatty acid-binding protein 4 might influence insulin sensitivity by effecting insulin signal pathway.Inflammation may involve in the mechanisms for retinol-binding protein 4 induced insulin resistance.Wnt-induced secreted protein-1 and secreted frizzle-related protein-5 play a role in inflammation through regulating Wnt signal pathway.Meanwhile,irisin can promote the burning of fat cells.Betatrophin may adjust glucose metabolism indirectly by regulating lipids metabolism.In conclusion,the mechanisms of cytokines are complex,the disorder of secretion is closely related to the occurrence and development of GDM.