摘要
目的制备并表征姜黄Curcumae longae Rhizoma提取物二氧化硅固体分散体。方法溶剂蒸发法制备固体分散体。体外溶出试验筛选提取物与载体(二氧化硅)比例,通过测定粒径、比表面积、孔隙率,观察微观形态,以及红外光谱、X射线进行表征。结果当提取物与载体比例为1∶8时,提取物中3种主要成分(双去甲氧基姜黄素、去甲氧基姜黄素、姜黄素)累积溶出率最高。与物理混合物相比,固体分散体粒径、比表面积、孔隙率更低。提取物以无定形状态分散于载体中。结论二氧化硅固体分散体可明显改善姜黄提取物中主要成分的溶出率。
AIM To prepare and characterize SiO_2 solid dispersions of Curcumae longae Rhizoma extract.METHODS For the solid dispersions prepared by solvent evaporation method,its ratio of extract to carrier( SiO_2) was screened by in vitro dissolution test,and the characterization was achieved by determination of particle size,specific surface area,porosity,micromorphology observation,infrared spectroscopy and X-ray. RESULTS When the ratio of extract to carrier was 1 ∶ 8,three main components(bisdemethoxycurcumin,demethoxycurcumin and curcumin) in the extract reached the highest accumulative dissolution rates. Compared with physical mixture,the solid dispersions demonstrated lower particle size,specific surface area and porosity. Extract was dispensed in the carrier in an amorphous state. CONCLUSION SiO_2 solid dispersions can obviously improve the dissolution rates of the main components in Curcumae longae Rhizoma extract.
出处
《中成药》
CAS
CSCD
北大核心
2018年第2期320-325,共6页
Chinese Traditional Patent Medicine
基金
国家自然科学基金资助项目(8127409881773918)
国家基础科学人才培养基金(J13100340-19)
关键词
姜黄提取物
二氧化硅固体分散体
制备
表征
溶剂蒸发法
体外溶出试验
Curcumae longae Rhizoma extract
SiO2 solid dispersions
preparation
characterization
solventevaporation method
in vitro dissolution test