中药干预慢性萎缩性胃炎的脑肠肽调节机制

Regulatory effect of traditional Chinese medicine on brain-gut peptides in chronic atrophic gastritis

慢性萎缩性胃炎(chronic atrophic gastritis,CAG)是临床中常见的一种消化系统疾病,属于胃癌前病变(precancerous lesions of gastric cancer,PLGC).现代医学研究证实,脑肠肽如胃促生长素、胃泌素、生长抑素和胃动素等,在CAG以及PLGC的发病机制中起重要作用.通过对脑肠肽水平的测定,可以辅助判断CAG的中医证型,评估其疾病进展和治疗效果.基于传统中医理论和脑肠互动学说,探讨中药干预CAG的脑肠肽调节机制,希冀为中医药防治CAG提供客观化的理论依据.

Chronic atrophic gastritis （CAG） is a common digestive system disease, which belongs to a type of precancerous lesion of gastric cancer （PLGC）. Modern medical research has shown that brain-gut peptides, such as ghrelin, gastrin, somatostatin, and motilin, play an important role in the pathogenesis of CAG and PLGC. In particular, brain-gut peptides can help to judge the traditional Chinese medicine （TCM） syndrome of CAG and thereby evaluate CAG progression and the therapeutic effect. Based on TCM theory and brain gut interaction, this paper discusses the regulatory effect of TCM intervention on brain-gut peptides in CAG, with an aim to provide a theoretical basis for TCM prevention and treatment of CAG.