钇-90微球放射栓塞治疗肝脏恶性肿瘤的不良反应和并发症--钇-90微球放射栓塞系列回顾(五)

Side effects and complications of yttrium-90 radioembolization therapy for hepatic malignancies.A series review of radioembolization with ^(90)Y microspheres(part Ⅴ)

钇-90(^(90)Y)微球放射栓塞是治疗肝脏恶性肿瘤的一种手段,已被多个国际肿瘤学和其他专业组织纳入指南。^(90)Y微球对肿瘤的杀伤作用主要来自其放射性,而不是缺血,因而与这一治疗相关的不良反应如乏力、恶心、呕吐,较为轻微但很常见。在较少的情况下,由于意外发生非靶器官栓塞,^(90)Y微球治疗可引起严重的并发症。本文将详细介绍^(90)Y微球治疗过程中可能出现的不良反应和各种并发症,对于这些不良反应与并发症的处理和治疗也作简单介绍。

Radioembolization with yttrium-90（^（90）Y）microspheres is an alternative treatment choice for hepatic malignancies and has become incorporated into guidelines by many international oncology and other professional organizations.The tumoricidal effects of radioembolization are predominantly derived from its radioactivity rather than ischemia.Therefore,the overall side effects that have been associated with this therapy,such as fatigue,nausea and vomiting,which are mild but common.Occasionally,severe complications may occur due to incidental embolization of non-target tissue by the^（90）Y microspheres.This review describes in detail the manifestation of side effects and various complications that may be associated with radioembolization using^（90）Y microspheres.Management and treatment options of these potential adverse events will also be discussed briefly.