N-氧化吡啶合成2-氨基吡啶酰胺的方法研究

The Study on the Synthesis of the 2-Aminopyridine Amides Using Pyridine-1-oxides

介绍了一种用N-氧化吡啶合成2-氨基吡啶酰胺的方法,一步法合成,安全,产率高并且条件温和。对反应催化剂的用量、反应温度和反应时间进行了优化,使2-氨基吡啶酰胺的产率达到90%。

The article describes a method Ior the synmesls ,the method has several advantages over previous methods:one-step synthesis, safety, high yield and mild conditions. In this paper, lhe reaction of the dosage of catalyst, temperature, time is optimized. Finally, the yield of 2-aminopyridine amides is reached 90%.