一种新的无催化剂条件下的2,3-喹啉二羧酸酯的合成

A New Catalyst-Free Synthesis of 2,3-Dicarboxylic Ester Quinoline Derivatives

无催化剂条件下,利用邻氨基二苯甲酮衍生物和丁炔二酸酯作为反应原料,二甲基亚砜(DMSO)作为溶剂,高效地构建2,3-喹啉二羧酸酯类化合物.并且根据反应的结果,对可能的反应机理进行了初步的探究.

A high efficient method for the synthesis of 2,3-dicarboxylic ester quinoline derivatives which employed o-amino diphenyl methylone derivatives and acetylenedicarboxylic esters as the reaction substrates was developed. This method possessed the character of catalyst-free and mild reaction conditions. Proposed mechanism was also studied according to the reaction result.