飞扬草化学成分的研究

Chemical constituents from Euphorbia hirta L.

为研究飞扬草的化学成分,利用溶剂提取法,正、反相硅胶柱和半制备高效液相色谱法对其乙酸乙酯提取物进行分离纯化,从飞扬草乙酸乙酯提取物分离得到11个化合物,并根据理化性质和波谱技术进行结构鉴定,分别鉴定为蒲公英萜醇(1)、蒲公英赛酮(2)、cycloart-23-ene-3β,25-diol(3)、25-hydroperoxycycloart-23-en-3β-ol(4)、吐叶醇(5)、黑麦草内酯(6)、β-谷甾醇(7)、cucurbic acid(8)、9,16-二羰基-10,12,14-三烯-十八碳酸(9)、3-烯-十六碳酸(10)、正二十四碳酸(11).其中化合物5、化合物9~化合物11为首次从飞扬草中分离得到.

To study the chemical constituents of Euphorbia hirta L stituents were isolated and purified by solvent extraction method, , the chemical con the normal and re verse phase silica gel column chromatography and semi-preparative HPI.C. Eleven compounds were isolated from the ethyl acetate extract of Euphorbiahirta L. and their structures were elucidated on the basis of chemical and spectroscopic analysis and the compounds were identified as taraxerol （ 1 ）, taraxerone （2）, cycloart-23-ene-3β3,25-diol （3）, 25-hydroperoxycycloart-23-en 3β-ol （4）, vomifoliol （5）, loliolide （6）, β-sitosterol （7）, cucurbic acid （8）, 9,16-dioxo-10,12,14-octadeca-trienoic acid （9）, hexadec-3-enoic acid （10）, and tetracosanoic acid （11）, respectively. Compound 5 and compound 9-11 were isolated from this plant for the first time.