摘要
miRNA是近年来发现的一类长度在18~25 nt的小分子RNA,它们不编码mRNA,但是在基因的转录水平或转录后水平上发挥重要的调控效应,控制着机体生长发育、分化、代谢和疾病等许多生物过程。近年来的研究表明,miRNA在哺乳动物生殖过程中起重要作用,miRNA表达异常与多种生殖道疾病密切相关,引起生殖力下降甚至不育。综述了miRNA的发现、生物合成与作用机制,以及在动物繁殖性能中的研究进展,以期为miRNA深入研究提供参考。
miRNAs are small RNAs of 18-25 nt in lengths discovered in recent years. They do not encode mRNAs,but play important regulatory roles in the transcriptional or post-transcriptional level of genes and control many biological processes including growth, differentiation, metabolism and disease. In recent years, studies have shown that miRNAs play an important role in the regulation of mammal reproduction. The abnormal expression of miRNAs is closely related to various genital diseases and leads to the decline of fecundity and even Infertility. This article summarizes the discovery, biosynthesis, working mechanisms of miRNAs as well as research progress in animal reproductive performance. It will provide reference for the further study of miRNA.
出处
《畜牧与饲料科学》
2018年第2期31-33,共3页
Animal Husbandry and Feed Science
基金
内蒙古自治区自然科学基金项目博士基金(2015BS0328)
国家自然科学基金项目(31360542)
国家肉羊产业技术体系建设项目(CARS-38)
内蒙古自治区农牧业科学院创新基金(2017CXJJM01-2)
