弥漫性泛细支气管炎13例临床分析

Clinical analysis of 13 patients with diffuse panbronchiolitis

目的分析弥漫性泛细支气管炎(DPB)的临床特点。方法回顾性分析13例DPB患者的临床资料,包括临床表现、主要辅助检查结果、治疗效果、随访和预后情况。结果咳嗽、咳痰、气促是最常见的症状。所有患者经治疗后咳嗽、咳痰症状均减轻,湿啰音减少,8例患者气促症状改善。出院前6例患者复查胸部CT,5例影像学改善明显。结论 DPB临床表现缺乏特异性。胸部影像学存在弥漫性结节样病变同时合并或曾经合并鼻窦炎病史,且同时存在以阻塞性通气功能障碍为主的肺功能异常患者,应注意有无存在DPB的可能。加强对DPB的认识是提高诊断率的关键。

Objective To analyze the clinical features of diffuse panbronchiolitis（DPB）.Methods The clinical data of 13 DPB cases were analyzed retrospectively,which included clinical manifestations,primary auxiliary examination results,therapeutic effects,follow-up and prognosis.Results The most common symptoms of DPB cases were cough,expectoration and shortness of breath.Cough,expectoration and the moist rale were decreased in all patients after treatment and shortness of breath was improved in 8 cases.The results of chest CT scan were significantly improved in 5 of 6 patients before discharged from hospital.Conclusion The clinical features of DPB lack of specificity.If diffuse lung nodules lesions exist in chest radiography with the history of sinusitis,as well as pulmonary function abnormalities,especially obstructive ventilation dysfunction,attention should be paid to the possibility of DPB.The key to improve the diagnosis rate is the understanding of DPB.