神经节细胞胶质瘤合并胚胎发育不良神经上皮性肿瘤1例并文献复习

Ganglioglioma associated with dysembryoplastic neuroepithelial tumor: a case report and literature review

目的探讨手术治疗神经节细胞胶质瘤(ganglioglioma,GG)合并胚胎发育不良性神经上皮肿瘤(dysembryoplastic neuroepithelial tumor,DNT)的难治性癫病例的病理及影像学特征,优化手术方案。方法回顾性分析1例症状性难治性癫病人的临床资料,经评估后行左额颞枕开颅左颞病变及癫灶切除术。结果术后病理为GG合并DNT,术后脑电图无癫样放电,病人恢复良好。随访1年无癫发作。结论 GG合并DNT的混合性神经元-胶质肿瘤临床少见,大多数为良性肿瘤,切除术后一般无复发,预后良好,无需进一步的放疗或化疗。

Objective To explore the pathological and imaging characteristics of intractable epilepsy patients with ganglioglioma（GG）and dysembryoplastic neuroepithelial tumor（DNT） and optimize the surgical procedures. Methods Clinical data of 1 patient with symptomatic intractable epilepsy were analyzed retrospectively, who received the left frontotemporal occipital craniotomy and resection of lesion of left temporal lobe and epileptogenic focus after evaluation. Results The postoperative pathological diagnosis was GG associtated with DNT. There was no epileptiform discharge in electroencephalogram after surgery. The patient recovered well and no seizure during one year followed-up period. Conclusion Mixed ganglioglioma of GG associated with DNT is rare and mostly is benign tumor. There is no relapse after surgery. The patient with tumor has favourable prognosis and further radiotherapy or chemotherapy is not necessary.