结肠癌腹腔镜手术的疗效与不良反应观察

Observation of the efficacy and adverse effects of laparoscopic surgery for colon cancer

目的探讨结肠癌采用腹腔镜手术治疗的临床疗效及不良反应。方法随机抽取2014年8月至2015年8月抚顺矿务局总医院老虎台分院收治的72例结肠癌患者作为研究对象。按照手术治疗措施不同将72例结肠癌患者分为研究组(腹腔镜手术,n=36)与对照组(开腹手术,n=36)。比较两组患者手术效果、复发转移情况及不良反应发生情况。结果研究组患者手术时间长于对照组,切口长度短于对照组,术中出血量少于对照组,住院时间、术后肛门排气时间均短于对照组,差异均有统计学意义(均P<0.05);研究组、对照组患者不良反应发生率分别为2.8%(1/36)、16.7%(6/36),差异有统计学意义(P<0.05)。随访24个月,研究组局部复发率为2.8%(1/36),远处转移率为8.3%(3/36);对照组局部复发率为5.6%(2/36),远处转移率为11.1%(4/36);两组患者局部复发率、远处转移率比较,差异均无统计学意义(均P>0.05)。结论结肠癌采用腹腔镜手术治疗效果理想,具有微创性特点,能促使患者术后尽快康复,且安全性较高,其远期局部复发率、远处转移率与开腹手术相似。

Objective To investigate the clinical efficacy and adverse reactions of laparoscopic surgery for colon cancer.Methods Methods a total of 72 patients with colon cancer who were treated in our hospital from August 2014 to August-2015 were randomly selected. According to the different surgical treatment measures, 72 cases of colon cancer patients were divided into study group（laparoscopic surgery, n=36） and control group（laparotomy, n=36）. The curative effect, recurrence, metastasis and adverse reactions were compared between the two groups.Results Study on the operation time is longer than the control group, the incision length is shorter than the control group, intraoperative bleeding was less than the control group, the hospitalization time is shorter than the control group, postoperative anal exhaust time shorter than the control group, the results were statistically significant（P〈0.05）;the study group and the control group of patients with adverse reaction rates were 2.8%（1/36）,16.7%（6/36）,the results were statistically significant（P〈0.05）;the study group were followed up for 24 months,the local recurrence rate was 2.8%（1/36）,distant metastasis rate was 8.3%（3/36）;the control group,the local recurrence rate was 5.6%（2/36）,distant metastasis rate was 11.1%（4/36）.The local recurrence rate and distant metastasis rate of the two groups were compared,the results were not statistically significant（P〈0.05）.Conclusion Laparoscopic surgery is an ideal and minimally invasive treatment for colon cancer.It can prompt patients to recover as soon as possible,and has high safety.Its long-term local recurrence rate and distant metastasis rate are similar to those of laparotomy.