PD-L1的表达与口腔鳞癌预后及临床病理特征相关性的meta分析

Clinicopathological and prognostic significance of PD-L1 expression in oral squamous cell carcinoma: a meta analysis

目的 :采用meta分析评价PD-L1的表达与口腔鳞状细胞癌(oral squamous cell carcinoma,OSCC)预后及临床病理特征的关系。方法:检索Pub Med、EMBASE以及Cochrane等数据库中关于PD-L1蛋白表达与OSCC预后和临床病理特征相关的实验研究,采用Rev Man 5.3软件进行meta分析。结果:最终纳入12个研究共1595例患者。Meta分析合并风险比(HR)为1.02(95%CI=0.93-1.11,P=0.71),表明PD-L1的表达与OSCC生存率无显著相关性。合并比值比(OR)显示,PD-L1与患者性别(OR=0.64,95%CI=0.48-0.85,P=0.002)、肿瘤分化程度(OR=0.58,95%CI=0.37-0.90,P=0.01)以及是否合并HPV感染(OR=1.91,95%CI=1.13-3.23,P=0.02)密切相关,但与肿瘤大小、颈淋巴结转移无明显相关性。结论:PD-L1的表达并不能作为判断OSCC预后的独立因素。在临床病理特征方面,PD-L1的表达与患者性别、肿瘤分化程度、HPV感染有显著相关性。该结论尚待更大样本的研究予以验证。

PURPOSE： To determine the prognostic role of high PD-L1 in patients with oral squamous cell carcinoma.METHODS： Electronic databases, such as Pub Med, Embase and Cochrane library, were searched to identify studies evaluating PD-L1 expression and overall survival（OS） in these patients. Rev Man 5.3 software was used for meta-analysis.RESULTS： A total of 12 studies that involved 1595 patients were included. Pooled hazard ratio（HR） 1.02（95% CI =0.93-1.11,P=0.71） indicated that the association between PD-L1 expression and overall survival（OS） was not significant.The pooled odds ratios（ORs） indicated that PD-L1 expression was associated with gender（OR=0.64, 95%CI=0.48-0.85,P=0.002）, differentiation（OR=0.58, 95%CI=0.37-0.90, P=0.01） and HPV infection（OR=1.91, 95%CI=1.13-3.23, P=0.02）.However, PD-L1 had no correlation with tumour size, and lymph node status. CONCLUSIONS： PD-L1 expression may not be an independent predictor of prognosis of patients with OSCC. Well-designed large cohort studies are needed to confirm these findings.