泛素化酶DNA损伤特异性结合蛋白2与肿瘤关系的研究进展

Progress of relationship between ubiquitinating enzyme damaged-DNA binding protein 2 and tumors

泛素化酶DNA损伤特异性结合蛋白2（DDB2）是一种DDB1-CUL4相关因子（DCAF）,属于泛素连接酶E3的亚家族.DDB2通过与DCAF相结合,形成泛素连接酶复合体,从而特异性识别靶蛋白底物,使底物泛素化并降解.其通过多种途径影响肿瘤的发生、发展,如DNA损伤修复、细胞周期调控及细胞凋亡、细胞侵袭与转移、细胞早衰、细胞增殖生长、肿瘤干细胞的群体化等.文章就DDB2影响肿瘤发生、发展的机制和对肿瘤治疗及预后判断的关系作一综述.

Ubiquitinating enzyme damaged-DNA binding protein 2 （DDB2） is a rind of DDB1 and CUL4-associated factors （DCAF）, and identifies belonging to the family of ubiquitinating E3 enzymes. DDB2 combines with CUL4-DDB1 to form the ubiquitin ligase complex, and identifies targets protein substrate specificity to make the substrate ubiquitin and degradation. It affects the development of tumors through various pathways, such as DNA damage repair, cell cycle regulation and apoptosis, cell invasion and metastasis, cell premature senescence, cell proliferation and cancer stem cell population. This paper reviews the progress of the relationship between DDB2 and the development, treatment and prognosis judgment of tumors.