金莲花颗粒联合头孢克肟治疗小儿急性呼吸道感染的临床研究

Clinical study on Jinlianhua Granules combined with cefixime in treatment of acute respiratory tract infection in children

目的探讨金莲花颗粒联合头孢克肟治疗小儿急性呼吸道感染的临床疗效。方法选取儋州市人民医院2015年9月—2016年9月收治的急性呼吸道感染患儿176例,随机分成对照组和治疗组,每组各88例。对照组患儿口服头孢克肟颗粒,体质量≥30 kg患儿,100 mg/次,体质量<30 kg患儿,3 mg/kg,2次/d;治疗组在对照组的基础上口服金莲花颗粒,每次1/3~1/2袋,3次/d。所有患儿均规律治疗5 d。观察两组患者临床疗效,比较治疗前后两组患儿IL-8、C反应蛋白(CRP)和降钙素原(PCT)水平以及主要临床症状消失时间和不良反应情况。结果治疗后,对照组临床总有效率为87.50%,显著低于治疗组的97.73%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组IL-8、CRP和PCT血清水平均较治疗前显著降低(P<0.05);且治疗组IL-8、CRP和PCT水平明显低于对照组(P<0.05)。治疗后,治疗组患儿体温恢复时间和咳嗽消失时间均显著短于对照组患儿,两组比较差异具有统计学意义(P<0.05)。治疗期间,对照组不良反应发生率为12.50%,明显高于治疗组的3.41%,两组比较差异具有统计学意义(P<0.05)。结论金莲花颗粒联合头孢克肟治疗小儿急性呼吸道感染疗效显著,安全性好,具有一定的临床推广应用价值。

Objective To explore the clinical effect of Jinlianhua Granules combined with cefixime in treatment of acute respiratory tract infection in children. Methods Children（176 cases） with acute respiratory tract infection in Danzhou People＇s Hospital from September 2015 to September 2016 were randomly divided into control and treatment groups, and each group had 88 cases. Children in the control group were po administered with Cefixime Granules, 100 mg/time for children weighed more than 30 kg, and 3 mg/kg for children weighed less than 30 kg, twice daily. Children in the treatment group were po administered with Jinlianhua Granules on the basis of the control group, 1/3 — 1/2 bag/time, three times daily. Children in two groups were treated for 5 d. After treatment, the clinical efficacy was evaluated, and IL-8, CRP and PCT levels, the disappearance time of main clinical symptoms, and adverse reaction in two groups before and after treatment were compared. Results After treatment, the clinical efficacy in the control group was 87.50%, which was significantly lower than 97.73% in the treatment group, with significant difference between two groups（P〈0.05）. After treatment, IL-8, CRP, and PCT levels in two groups were significantly decreased（P〈0.05）. And the IL-8, CRP, and PCT levels in the treatment group were significantly lower than those in the control group（P〈0.05）. After treatment, the temperature recovering time and coughing disappearance time in the treatment group were significantly shorter than those in the control group, with significant difference between two groups（P〈0.05）. During the treatment, the incidence of adverse reactions in the control group was 12.50%, which was significantly higher than 3.41% in the treatment group, with significant difference between two groups（P〈0.05）. Conclusion Jinlianhua Granules combined with cefixime has significant effect in treatment of acute respiratory tract infection in children with high safety, which has a certain clinical application value.