新生儿缺氧缺血性脑病血浆SOD、NPY测定的临床意义

The Clincal Significance of Determining the Plasma Superoxide Dismutase and Neuropeptide Y in Newborn Hypoxic-ischemic Encephalopathy

目的 :探讨新生儿缺氧缺血性脑病 (HIE)患者血浆超氧化物歧化酶 (SOD)、神经肽Y(NPY)在各临床分度中的含量及其在疾病中的临床意义。方法 :应用放射免疫分析 (RIA)测定 6 3例HIE患儿血浆SOD、NPY进行综合检测和相关性研究。结果 :SOD、NPY放免测定结果在HIE各临床分度中含量各异 ,与正常对照组均存在明显差异 (p值均 <0 0 5或 <0 0 1)。结论 :HIE患儿血浆SOD、NPY含量与疾病临床分度呈正相关 ,与疾病危重程度、发生发展、预后有关。

Objective To investigate the contents of plasma superoxide dismutase (SOD) and neuropeptide Y(NPY) in newborn hypoxic-ischemic encephalopathy(HIE) babies in various clinic stages and their clinical significance. Methods The plasma levels of SOD and NPY of 63 HIE babies and controls were determined by radioimmunoassay(RIA) and the values were studied for different clinical stages (severe 22, modeate 7 and mild 24). Results The contents of plasma SOD and NPY of HIE babies of various stages were different and there existed remarkable contrast between those in patients and controls ( p <0 05 or p <0 01). Conclusion The contents of plasma SOD and NPY in HIE neonates were correlated to the clinic stage and severeness of the disease proces.