血清降钙素原动态检测在脑出血合并感染患者预后评估中的价值

Value of dynamic detection of PCT in prognostic evaluation in patients with cerebral hemorrhage complicated with infection

目的动态检测脑出血合并感染患者血清降钙素原(PCT)并研究其在预后评估中的价值。方法选择2014年8月-2016年9月ICU收治的脑出血患者120例为研究对象,根据患者是否合并感染分为感染组50例和未感染组70例,比较两组患者入住ICU后第1d、第3d、第5d和第7d血清PCT水平差异,分析感染组患者中死亡和存活患者血清PCT的差异,研究血清PCT在判断脑出血合并感染死亡的特异度和灵敏度。结果感染组脑出血患者入住ICU后第1d、第3d、第5d和第7d血清PCT分别为(3.18±1.04)、(5.72±1.54)、(4.92±1.36)和(2.21±0.95)ng/ml均高于未感染组患者(P<0.001)。感染组脑出血中死亡患者入住ICU后第1d、第3d、第5d和第7d血清PCT分别为(3.40±1.02)、(7.11±1.50)、(6.81±1.25)和(4.01±0.91)ng/ml高于存活脑出血患者(P均<0.05)。血清PCT在判断脑出血合并感染死亡的临界值为6.50ng/ml,特异性为0.620,灵敏度为0.840。结论脑出血合并感染患者血清PCT升高较明显,血清PCT在预测脑出血合并感染死亡中具有重要价值。

OBJECTIVE To detect procalcitonin（PCT）in patients with cerebral hemorrhage complicated with infection and study its value in prognostic evaluation.METHODS A total of 120 cases of patients with cerebral hemorrhage from Aug.2014 to Sep.2016 were selected and divided into patients with infection（infection group,50 cases）and patients without infection（non-infection group,70 cases）.The differences of serum PCT between infection group and non-infection group at 1 d,3 d,5 dand 7 dafter admission to ICU were compared.The differences of PCT between dead patients and survival patients in infection group were analyzed.The sensitivity and specificity of PCT in the death prediction for patients with intracerebral hemorrhage complicated with infection were analyzed.RESULTS The PCT at 1 d,3 d,5 dand 7 dafter admission to ICU in infection group were（3.18±1.04）,（5.72±1.54）,（4.92±1.36）and（2.21±0.95）ng/ml,which were significantly higher than those in non-infection group（All P〈0.05）.The PCT at 1 d,3 d,5 dand 7 dafter admission to ICU in death patients were（3.40±1.02）,（7.11±1.50）,（6.81±1.25）and（4.01±0.91）ng/ml,which were significantly higher than those in survival patients（P〈0.05）.The critical value of PCT in the death prediction for patients with intracerebral hemorrhage complicated with infection was 6.50 ng/ml,and the sensitivity and specificity were 0.620 and 0.840 respectively.CONCLUSIONPCT levels are significantly increased in patients with cerebral hemorrhage complicated with infection,and serum PCT is of great value in predicting the death of cerebral hemorrhage complicated with infection.