二硫键在药物研发中的应用及其研究进展

Application and research progress of disulfide bonds in drug development

二硫键作为重要的化学基团在天然产物结构中广泛存在,一些含有二硫键的化合物表现出很好的生物活性,包括抗肿瘤、抗氧化、抗菌和酶抑制活性等。近年来,基于二硫键的氧化还原响应性药物传递系统特异性的释放抗肿瘤药物更是成为研究热点。本文主要介绍含有二硫键的单体药物以及药物-载体缀合物的研究进展,并概述其化学结构、药理作用以及二硫键的生物化学功能。

Disulfide bonds are widely distributed in natural products as important chemical groups. Some com- pounds containing disulfide bonds exhibit good biological activities, including anti-tumor, anti-oxidation, en- zyme inhibition and antibacterial activities. In recent years,redox-responsive drug delivery systems that speci- fically release drugs based on disulfide bonds in tumor cells have become a research highlight. In this paper, the development of drugs and the drug-cartier conjugates containing disulfide bonds were reviewed and the chemical structures, pharmacological properties and biochemical functions of disulfide bonds were summa- rized.