摘要晚期恶性肿瘤骨转移时常出现疼痛，其性质较为顽固且不易缓解。随着病情进展骨骼相关事件（skeletal related event，SRE）也相应增加，比如：病理性骨折、高钙血症、骨功能障碍等。临床治疗除了针对具体肿瘤采取手术、化疗、放疗、激素及靶向药物等治疗手段外，还需积极控制疼痛及骨相关事件的发生。
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