氨基酸微量元素螯合物―蛋氨酸铜的制备工艺研究

Preparation of amino acid based trace elements chelates—copper methionine

氨基酸微量元素螯合物作为新一代微量元素添加剂,具有良好的化学稳定性、易消化吸收性、生物学高效价性等优点,是一种安全环保的新型绿色添加剂。本文采用蛋氨酸为前驱体,研究其微量元素鳌合物―蛋氨酸铜的化学合成。通过正交实验L_9(3~4)设计确定了蛋氨酸铜的最佳合成工艺,分析了多种实验条件对蛋氨酸铜合成的影响。实验表明,有机铜源具有比无机铜源更高的产品收率,最佳工艺条件是:蛋氨酸和乙酸铜的摩尔比为3:1,反应温度为80℃,反应时间为2.0 h,蛋氨酸的初始浓度为0.40 mol/L。最后,通过红外光谱、紫外—可见吸收光谱、X射线粉末衍射及热重分析等手段对所合成的螯合物的结构及性质进行分析。该制备工艺简单,产率较高,成本很低,无污染,具有非常好的工艺应用前景。

As a new generation of trace element additives,amino acid-based trace element chelates have exhibited some distinct advantages such as good chemical stability,easy digestion and absorption,and high biological efficiency. Therefore,it is considered as a safe,environmentally-friendly green additive. In this paper,the synthesis of copper methionine―a chelate of amino acid-based trace element was investigated in using methionine as the amino acid precursor. The optimum operational parameters were obtained by orthogonal experiment L_9（3~4）. The influence on the yield of copper methionine was analyzed. The results indicated that organic copper compound had a higher yield than inorganic ones,and the optimal reaction conditions were determined as follows ：nmethionine ：nCu（AC）2 = 3.0,reaction temperature 80 ℃,reaction interval 2.0 h and initial methionine concentration 0.40 mol/L. Finally,IR spectrum,UV-vis spectrum,XRD and TGA were used to characterize the structure and physiochemical properties. In summary,this new technique of preparing copper methionine chelate has the advantages on its simplicity,high yield,low cost and non-pollution. It has a potential applicable prospect in nutrition additives in the future.