摘要
帕金森病(PD)是一种慢性进行性神经系统变性疾病。患者黑质纹状体多巴胺能神经元的变性脱失会伴随有突触前膜多巴胺转运蛋白(DAT)数量及功能的明显下降。DAT显像剂11C—Ahropane可与DAT特异性结合,且比同类药物吸收快、具有更高的亲和力,能直接、灵敏地反映突触前多巴胺能神经元的变化,是PD早期诊断的最佳手段。笔者介绍了PD诊断的现状、PET显像剂的原理及发展过程、11C-Altropane的合成及其作为PET显像剂在临床研究巾的应用。
In patients with Parkinson's disease(PD), a chronic progressive neurological degeneration order, the degeneration and loss of dopaminergic neurons in the substantia nigra is generally associated with the significant decrease in the number and disrupted function of dopamine transporters(DATs) in tile presynaptic membrane, 11C-Altropane, a DAT-imaging agent, can specifically binds with DAT and directly reflects the changes in presynaptic dopaminergie neuron. In this paper, the synthesis of 11C-Altropane and its application as a PET imaging agent in clinical research were reviewed.
出处
《国际放射医学核医学杂志》
2018年第1期74-79,共6页
International Journal of Radiation Medicine and Nuclear Medicine
基金
中国医学科学院医学与健康科技创新工程项目(2016-12M-3-022、2017-12M-3-019)