特异性免疫治疗依存性的研究进展

Progress in the study of dependence Of specific immunotherapy

过敏性疾病是慢性疾病，其发病率极高、易反复、控制不佳、预后差，是全球性难题。依从性差是慢性疾病长期治疗中常见的世界性问题。过敏原是过敏性疾病的主要病因，而特异性免疫治疗（SIT）是针对过敏原影响免疫机制使机体产生免疫耐受从而治疗过敏性疾病的方法，有效性及安全性已得到广泛证实。但目前最常见过敏原的SIT依存性差，而依存性是疗效的关键。这迫切需要探究SIT依存性差的影响因素及相应措施，以提高SIT在过敏性疾病治疗中的应用，从而使疾病得到更好的控制、改善疾病预后、提高患者生活质量、减轻社会经济负担。

Allergic disease is a chronic disease,its incidence rate is extremely high, easy to relapse, poorly controlled, poor prognosis, is a global problem. Poor compliance is a common worldwide problem in long-term treatment of chronic diseases. Allergen is a major cause of allergic diseases, and specific immunotherapy （SIT） is a method of treating allergic diseases by allergens affect the immune mechanism to make the body immune tolerance, validity and safety have been widely confirmed. However, the SIT dependence of the most common allergens is poor at present, and the dependence is the key to the curative effect. This is an urgent need to explore influencing factors and corresponding measures of the poor dependence of SIT, so as to improve the application of SIT in the treatment of allergic diseases, so that the disease can be better controlled, improve the prognosis of the disease, improve the patient quality of life and reduce the socio-economic burden.