黄酮类化合物磷脂复合物的制备与功能活性研究进展

Advance of the Preparation and Biological Activity of Flavonoid Phospholipid Complex

黄酮类化合物具有诸多生物活性,但因其脂溶性差、生物利用度低等问题,严重制约了在生物医药领域的应用。近年来对黄酮类化合物改性技术及开发备受关注,例如黄酮磷脂复合物的制备可显著增强黄酮的脂溶性,促进其在消化道中的吸收,提高黄酮类的生物利用度。本文对国内外黄酮磷脂复合物的制备、药动学及功能活性方面的应用研究进行综述,旨在为日后对黄酮类化合物临床应用价值的开发提供依据。

To address the problems that flavonoids are difficult to be absorbed and utilized due to their high polarity and poor lipid solubility, the modification of flavonoids has attracted much attention in recent years. The development of flavonoid phospholipid complex, which can significantly enhance the lipid solubility of flavonoids, promote the absorption in the intestine, and improve the bioavailability, is a key to address these problems. This article reviewed the preparation, pharmacokinetics, and functional activity of flavonoid phospholipid complex, aimed to provide technical supports for the further research and clinical application.