布地奈德雾化联合孟鲁司特钠对小儿咳嗽变异性哮喘疗效及复发的影响观察

The effect of Budesonide combined with Montelukast on cough variant asthma (CAV) in children and its recurrence

目的探讨布地奈德雾化联合孟鲁司特钠化对小儿咳嗽变异性哮喘(CAV)疗效及复发的影响。方法以62例CAV患者为研究对象,随机分为观察组(32例,常规治疗+布地奈德雾化+孟鲁司特钠口服)和对照组(30例,给予常规治疗+布地奈德雾化),观察2组疗效及复发情况。结果观察组总有效率93.8%(30/32),对照组73.3%(22/30),差异有统计学意义(P<0.05)。随访1年,观察组复发2例(6.3%),对照组5例(16.7%),观察组复发间隔时间明显较长,复发后再次使用布地奈德雾化治疗时间也明显较短,与对照组比较差异具有统计学意义(P<0.05)。结论在常规治疗的基础上上使用布地奈德雾化吸入配合孟鲁司特钠口服治疗CAV能明显提高疗效,降低复发率,减少复发频率。

Objective To investigate the effect of budesonide mist combined with montelukast on CAV in children and its recurrence.Methods 62 patients with CAV as the research object were divided into observation group（32 cases,conventional therapy ＋budesonide＋montelukast） and control group（30 cases,conventional therapy ＋ budesonide）,curative effect and recurrence of two groups were observed.Results The total effective rate was 93.8%（30/32）in the observation group and 73.3%in the control group（22/30）,and the difference was significant（P〈0.05）.1 years of follow-up,there were 2 cases of recurrence（6.3%）in observation group and 5 cases（16.7%）in control group.Compared with control group,observation group recurrence time was significantly longer and the time using budesonide treatment after recurrence was significantly shorter（P〈0.05）.Conclusion Based on the conventional therapy,inhalation of budesonide combined with montelukast in the treatment of CAV can significantly improve the curative effect,and reduce the recurrence rate and frequency of recurrence,which worthy of further clinical exploration and popularization.