羟考酮缓释片联合吗啡对重度癌痛患者的疗效观察及生活质量的影响

Curative efficacy of oxycodone hydrochloride sustained release tablet combined with morphine tablets in the treatment of patients with severe cancer pain and its influence on quality of life

目的 研究羟考酮缓释片联合吗啡片对重度癌痛患者的临床疗效及其对生活质量的影响.方法 选取90例重度癌痛患者作为研究对象.采用随机数字表法分为观察组和对照组,各45例.对照组采用吗啡片治疗,观察组采用羟考酮缓释片联合吗啡片治疗.观察两组不良反应,生活质量评分,疼痛缓解情况.结果 两组不良反应发生率差异无统计学意义（x2 =1.216,P＞0.05）;观察组食欲、睡眠、日常活动、精神状态、情绪、与人交往、生活兴趣评分均小于对照组[（3.20±0.78）分比（5.36±0.90）分、（2.80±0.80）分比（4.39±0.72）分、（3.40±0.51）分比（4.98±0.60）分、（2.33±0.41）分比（4.58±0.50）分、（3.59±0.45）分比（5.90±0.50）分、（3.56±0.42）分比（4.98±0.45）分、（3.18±0.92）分比（5.87±1.01）分,t=12.166、9.910、13.460、23.343、23.036、15.475、13.208,均P＜0.05];观察组疼痛缓解率高于对照组[95.55％（43/45）比80.00％ （36/45）,x2=5.075,P＜0.05].结论 羟考酮缓释片联合吗啡片对重度癌痛患者的疗效显著,能够缓解患者的痛苦,改善患者的生活质量.

Objective To study the curative efficacy of oxycodone hydrochloride sustained release tablet combined with morphine tablets in the treatment of patients with severe cancer pain,and its influence on quality of life.Methods 80 patients with severe cancer pain were selected as research subjects.They were randomly divided into observation group and control group,45 cases in each group.The control group was treated with morphine tablets,while the observation group was treated with oxycodone hydrochloride sustained release tablet combined with morphine tablets.Then,the adverse reaction,quality of life score,pain relief were compared between the two groups.Results After treatment,there was no significant difference in the incidence of adverse reactions between the two groups （x2 =1.216,P ＞0.05）.The appetite,sleep,daily activities,mental state,emotion,and interpersonal,life interest score in the observation group were lower than those in the control group[（3.20 ±0.78） points vs.（5.36 ±0.90） points,（2.80 ± 0.80）points vs.（4.39 ± 0.72） points,（3.40 ± 0.51） points vs.（4.98 ± 0.60） points,（2.33 ± 0.41） points vs.（4.58 ± 0.50） points,（3.59 ± 0.45） points vs.（5.90 ± 0.50） points,（3.56 ± 0.42） points vs.（4.98 ± 0.45） points,（3.18 ± 0.92） points vs.（5.87 ± 1.01） points,t =12.166,9.910,13.460,23.343,23.036,15.475,13.208,all P ＜0.05].The pain relief rate of the observation group was statistically higher than that of the control group[95.55％ （43/45） vs.80.00％ （36/45）,x2 =5.075,P ＜ 0.05].Conclusion Oxycodone hydrochloride sustained release tablet combined with morphine tablets has significant effect on cancer patients,and it can alleviate the suffering of patients,improve the quality of life of patients.