红蓝光联合红霉素凝胶治疗痤疮疗效观察

Effect of red and blue light combined with erythromycin gel in ther treatment of acne

目的 探讨红蓝光联合红霉素凝胶治疗痤疮的临床效果.方法 选取100例痤疮患者,采用随机数字表法分为两组,每组50例.观察组用红蓝光联合红霉素凝胶治疗,对照组只用红霉素凝胶治疗,比较两组临床效果及患者生活质量的改善情况.结果 观察组与对照组总有效率（90％比70％）差异有统计学意义（x2 =6.250,P=0.023）;治疗后两组患者在自我感知[（14.28±1.05）分比（14.28±1.05）分]（t=6.009,P =0.007）、痤疮分布情况[（14.00±2.25）分比（14.69±2.05）分]（=6.028,P=0.006）、情感功能[（13.50±2.20）分比（13.27±2.01）分]（t=7.827,P=0.001）、社会功能[（11.03±1.84）分比（11.30±1.79）分]（t=5.892,P=0.012）、总体认知[（13.33±1.05）分比（13.00±1.23）分]（t=5.772,P=0.015）等差异均有统计学意义（均P ＜0.05）;两组不良反应发生率（4％比24％）差异有统计学意义（x2=8.306,P =0.008）.结论 红蓝光联合红霉素凝胶治疗痤疮比单独应用红霉素凝胶效果好,并发症少,患者生活质量改善明显.

Objective To study the effect of red and blue light combined with erythromycin gel in ther treatment of acne.Methods 100 acne patients were selected,they were randomly divided into two groups according to the digital table,50 cases in each group.The observation group was treated with red and blue light combined with erythromycin gel,the control group was treated with erythromycin gel alone.The improvement of the quality of life and treatment effect were compared.Results The difference of total effective rate between the observation group and the control group was statistically significant （90％ vs.70％,x2 =6.250,P =0.023）.After treatment,the self-perception [（14.28 ± 1.05） points vs.（14.28 ± 1.05） points,t =6.009,P =0.007],acne distribution [（14.00 ± 2.25） points vs.（14.69 ± 2.05） points,t =6.028,P =0.006],emotional function [（13.50 ± 2.20） points vs.（13.27 ± 2.01） points,t =7.827,P =0.001],social function [（11.03 ± 1.84） points vs.（11.30 ± 1.79） points,t =5.892,P =0.012],overall cognition [（13.33 ± 1.05）points vs.（13.00 ± 1.23） points,t =5.772,P =0.015] had statistically significant differences between the two groups （all P ＜ 0.05）.The incidence rate of adverse reactions between the two groups had statistically significant difference （4％ vs.24％,x2 =8.306,P =0.008）.Conclusion Red and blue light combined with erythromycin gel in the treatment of acne has good effect,less complications,it can significantly improve quality of life of patients.