原发性高血压患者血清谷氨酰转肽酶与左心房内径的相关性研究

Relationship between left atrial diameter with serum glutamyl transpeptidase level in patients with essential hypertension

目的 探讨原发性高血压患者左心房内径与血清谷氨酰转肽酶的关系及临床意义.方法 选取资料完整的原发性高血压患者200例,根据经胸超声心动图检查结果分为左心房增大组和左心房正常组.测量患者肝肾功能、血脂、血压、血糖等指标并进行统计分析.结果 在原发性高血压患者中,左心房增大组血清谷氨酰转肽酶水平[（21.56±11.95） U/L比（37.28±12.64） U/L]明显低于左心房正常组（P=0.001）,差异有统计学意义.Spearman相关分析表明血清谷氨酰转肽酶与左心房内径呈负相关（r=-0.413,P=0.002）,多因素线性回归分析仍显示血清谷氨酰转肽酶与左心房内径呈负相关（β=-0.394,95％ CI：-0.131,-0.692,P=0.005）.结论 原发性高血压患者血清谷氨酰转肽酶水平与左心房大小呈负相关关系,监测血清肝酶变化可能对早期发现心房增大有一定意义.

Objective To analyze the relationship and clinical significance of serum glutamyl transpeptidase （GGT） level with left atrial diameter.Methods All the newly diagnosed 200 essential hypertension patients with complete data were selected.They were divided into normal left atrial group and enlarged left atrial group based on the size of left atrial diameter.Fasting blood glucose,serum lipid,routine laboratory tests,hepatic and renal function and blood pressure were measured by routine methods,and compared between the two groups.Results The GGT level in the enlarged left atrial group was lower than that in the normal left atrial group among essential hypertension patients [（21.56 ± 11.95） U/L vs.（37.28 ± 12.64） U/L] （P =0.001）.Spearman correlation showed that GGT level was negatively associated with left atrial diameter（r =-0.413,P =0.002）.Multiple linear regression analysis showed that the serum GGT was also negatively correlated with left atrial diameter（β =-0.394,95 ％ CI：-0.131,-0.692;P =0.005）.Conclusion Our study demonstrated that the level of GGT was negatively correlated with left atrial diameter among essential hypertension patients,and monitoring the changes of serum liver enzyme may have significant effect on the early detection of enlarged left atrial diameter.