红细胞分布宽度对食管癌的预测价值

Predictive value of red blood cell distribution width to esophageal cancer

目的探讨红细胞分布宽度(RDW)对食管癌(EC)患者的临床预测价值。方法选取本院2014年1月-2016年9月124例诊断为食管癌的患者作为疾病组,并选取同期来院体检的150例健康者作为对照组。收集2组对象的一般人口学数据和临床资料,并抽取外周血检测血常规、生化等指标。结果疾病组RDW、NLR、hs-CRP、PDW和PLR水平高于对照组,疾病组Hb、LDL、白蛋白和前白蛋白水平低于对照组,差异均有统计学意义(P<0.05),而其他指标在2组间差异无统计学意义(P>0.05)。RDW对EC诊断的ROC曲线下面积(AUC)为0.782。非条件Logistic回归分析显示,RDW可作为EC的独立预测指标(OR=2.006,95%CI:1.523~2.698,P=0.01)。结论高水平的RDW与食管癌的发生相关,且是食管癌的一个预测因子,RDW检测对于预测EC具有一定的临床价值。

Objective To explore the predictive value of red blood cell distribution width（ RDW） in patients with esophageal cancer（ EC）. Methods 124 EC patients and 150 healthy controls from the First Affiliated Hospital of Soochow University from January 2014 to September 2016 were collected as the patients group and the control group respectively. Demographic data were collected for routine blood tests and biochemistry examination. Results The levels of RDW,NLR,hs-CRP,PDW and PLR in patients with EC were higher than those in the controls. Hb,LDL,Albumin and Prealbumin levels in patients with EC were lower than those in the controls（ all P 〈 0. 05）. There was no statistical significance on the difference in other markers between the 2 groups（ P 〉 0. 05）. The area under the ROC curve（ AUC） of RDW in the diagnosis of EC was 0. 782. Based on unconditional Logistic regression analysis,RDW could be used as an independent predictor of EC（ OR = 2. 006,95% CI： 1. 523-2. 698,P = 0. 01）. Conclusion High level of RDW is associated with the occurrence of esophageal cancer,and is a predictor of esophageal cancer. RDW may have clinical value in predicting esophageal cancer.