乳腺癌根治术后不同放疗技术的应用与剂量分析

Application and dose analysis of different radiotherapy techniques after radical mastectomy for the breast cancer

目的 :分析乳腺癌根治术后不同放疗技术的应用与剂量。方法 :选取2012年2月至2016年4年收治的乳腺癌根治术后患者30例,随机分为对照组与观察组各15例。对照组采用普通放疗计划,观察组采用三维适形放疗,均根据处方剂量50 Gy进行放疗。观察比较两组计划靶区(PTV)剂量参数、分次治疗时间以及近期不良反应。结果 :观察组PTV各剂量参数显著低于对照组(P<0.05),分次治疗时间明显短于对照组(P<0.05),近期不良反应发生率为6.67%(1/15),低于对照组的20.0%(3/15,P<0.05)。结论 :乳腺癌根治术后采用三维适形放疗的效果更为显著,即靶区剂量覆盖均匀性显著较高,且能显著减少危急器官的平均剂量以及高剂量区体积,同时还能减少各种近期不良反应,值得推广应用。

Objective： To analyze the application and dosage of different radiotherapy techniques after radical mastectomy. Methods： Thirty cases of breast cancer after radical mastectomy in 4 years from February 2012 to February 2016 were selected and randomly divided into a control group and an observation group with 15 cases each. The control group was treated with a general radiotherapy plan, and three-dimensional conformal radiotherapy was used in the observation group and the radiotherapy was performed on the basis of prescription agent 50 Gy. The dose parameters, fractional treatment time and short-term adverse reactions of planned target area （PTV） in two groups were observed and compared. Results： The dose of PTV in the observation group was signifcantly lower than that in the control group（P〈0.05）. The treatment time of the observation group was signifcantly shorter than that of the control group（P〈0.05）. The incidence of recent adverse reactions was 6.67%（1/15）, which was lower than that of the control group 20%（3/15）（P〈0.05）. Conclusion： The efect of Three-dimensional conformal radiotherapy is more signifcant after radical mastectomy. That is the dose coverage uniformity in the target area is signifcantly higher, and it can signifcantly reduce the average dose of critical organs and the volume of high dose area. At the same time, it can also reduce a variety of adverse reactions in the near future, which is worth popularizing.