microRNA-196a与肿瘤相关性的研究进展

Research progress on the relationship between microRNA-196a and tumor

microRNA-196a(miR-196a)作为miRNA家族中的成员之一,近年来受到了广泛关注。miR-196a不但在多种生物学过程中起重要的调控作用,同时还有研究表明在肿瘤的发生发展中miR-196a还发挥类似癌基因的功能。研究发现,miR-196a在肿瘤患者的血清、组织及细胞中呈高表达,而且能够促进肿瘤细胞增殖、侵袭及转移,抑制肿瘤细胞凋亡,增强肿瘤耐药性。本文结合国内外最新报道对miR-196a与肿瘤相关性研究进展做一综述。

As a member of the miRNA family,microRNA-196 a（ miR-196 a） has received much attention in recent years.MiR-196 a not only plays an important regulatory role in various biological processes,but it also shows that miR-196 a also functions as oncogene in the tumorigenesis and progression. In recent studies,miR-196 a is high expression in the serum,tissues and cells of patients with cancer,and can promote tumor cell proliferation,invasion and metastasis,inhibit tumor cell apoptosis and enhance tumor drug resistance. In this paper,we reviewed the research progress on the correlation between miR-196 a and tumor based on the latest reports at domestics and abroad.