摘要
WEE1属于丝/苏氨酸蛋白激酶家族,其可以通过抑制CDC2的活性来抑制细胞进行有丝分裂,调节细胞周期进展。越来越多的研究表明人WEE1在维持癌细胞生存方面具有非常重要的作用,是一个理想的癌细胞治疗靶点。现就WEE1基因及蛋白的调节,WEE1在人癌细胞中的表达、靶向治疗,以及目前研究存在的问题作一综述。
WEE1,serine/threonine protein kinase,can inhibit the mitosis and regulate the cell cycle progress by inhibiting the activity of CDC2. Many studies have shown that human WEE1 plays an important role in cancer cell survival,and is an ideal target for cancer cell therapy. This review focuses on the WEE1 regulation,the expression of WEE1 and its effect as a target in human cancer cells,as well as the existing problems should be futher explored.
出处
《转化医学电子杂志》
2018年第2期9-14,共6页
E-Journal of Translational Medicine
基金
广东省自然科学基金(2017A030307012)
广东省韶关市科技局项目(2017cx/018)
