肾癌肾脏供肾移植的系统研究

Systematic Review for Donor Kidneys with Renal Cell Cancer

目的通过系统检索和分析文献,荟萃相关证据,系统地评价肾癌肾脏供肾的的研究现状。方法在中国知网、万方、维普、CBM、PubMed、Embase、Cochrane Library和ClinicalTrials.gov等数据库,通过制定完备的检索策略,无语言限制地检索相关文献,人工检索入选文献的参考文献避免遗漏。两名评述者根据预先制定好的文献纳入和排除标准独立地筛选文献,按预制好的表格提取纳入文献中相关资料,数据获取后,汇编成表,计算总的肿瘤复发率。结果一共有1920篇文献被检索出,通过筛选,19个研究被最终被纳入系统评价,这19个研究均为病例报道或病例系列研究。通过对现有文献的系统综述,目前总共有104例小肾癌肾脏被用作供肾,肾移植后均未发生明确的肾癌复发。结论现有的证据表明,小肾癌肾脏作为供肾,肾移植后肾癌的复发率相对很低,值得进一步地深入研究和应用。

Objective To review the literature and synthesize current evidence on the use of kidneys with small renal cancer as donor kidneys. Methods To locate eligible studies,several databases including CNKI,Wanfang,Weipu,CBM,PubMed,Embase,Cochrane Library and ClinicalTrials. gov were screened,while key informants were collected and bibliographies of included studies were scrutinised. Two reviewers independently assessed studies for inclusion,extracted data. Data were synthesised as a narrative review. Results 1920 articles were found,while eventually 19 studies were selected for this systematic review. All of the 19 included studies were case reports or case series. Totally 104 documented cases of donor kidneys after resection of small renal cancer were transplanted and no definite recurrence happened. Conclusions It is suggested from current limited evidence that cancer recurrence rate of all transplanting kidney after resection of SRC was relatively low,thus it deserved much more well-designed clinical trials and clinical use.