Treg细胞和Th17细胞在炎症性肠病治疗中的作用

Roles of Treg Cells and Th17 Cells in Treatment of Inflammatory Bowel Disease

炎症性肠病(IBD)是一类非特异性肠道炎症性疾病,肠道黏膜免疫失衡是诱导IBD发生的主要原因之一。调节性T细胞(Treg细胞)是重要的免疫调控细胞,辅助性T细胞17(Th17细胞)参与宿主免疫防御,两者之间的平衡是维持肠道免疫稳态的重要因素。本文就Treg细胞和Th17细胞在IBD治疗中的作用作一综述。

Inflammatory bowel disease( IBD) is a kind of non-specific intestinal inflammatory disease. The immune imbalance of intestinal mucosa is the main cause of IBD. Regulatory T cells( Treg cells) are important immune-regulatory cells,and helper T cells 17( Th17 cells) participate in host immune defense. The balance between Treg cells and Th17 cells is an important factor to maintain intestinal immune homeostasis. This article reviewed the roles of Treg cells and Th17 cells in the treatment of IBD.