胺碘酮对心律失常患者QT间期、QTd的影响及其临床意义

Influence and clinical significance of amiodarone on QT interval and QTd in patients with arrhythmia

胺碘酮是常用广谱抗心律失常药,但临床应用常导致QT间期延长、QT离散度(QTd)增大和尖端扭转性室速(Tdp)等恶性心律失常事件发生率增加。尤其是>60岁老年患者临床应用胺碘酮时应密切监测心电图及关注QT间期、QTd,降低恶性心律失常和心源性猝死发生率,提高救治率,改善患者预后。本文针对胺碘酮的使用对QT间期、QTd的影响及其临床意义进行综述,以期引起临床医生重视。

Amiodarone is a commonly used broad-spectrum antiarrhythmic drug,however,clinical applications often lead to an increase in the incidence of malignant arrhythmia events,such as QT interval extension,QT dispersion increase and torsades de points.Especially in elderly patients older than 60 years old,we should closely monitor the ECG and QT interval and QTd during the clinical application of amiodarone,so as to reduce the incidence of malignant arrhythmia and sudden cardiac death,improve the treatment rate and improve the prognosis of patients.This article reviewed the effect of amiodarone on QT interval and QTd and its clinical significance,in order to attract the attention of clinicians.