25-羟维生素D在狼疮性肾炎中的表达水平及意义

The expression level and significance of 25 hydroxyvitamin D in lupus nephritis

目的:探讨25-羟维生素D[25(OH)D]在狼疮性肾炎(LN)患者外周血的表达水平及临床意义。方法:初诊系统性红斑狼疮(SLE)患者,按有无LN分为两组,收集SLE患者的临床及实验室资料。纳入健康体检者为对照组。测定3组血清25(OH)D水平,分析LN患者血清25(OH)D水平与临床及实验室指标的关系。结果:LN患者和无LN的SLE患者25(OH)D水平均低于对照组(P<0.01);LN患者血清25(OH)D水平分别与24 h尿蛋白定量呈负相关,与C3呈正相关,而与SLEDAI评分、抗dsDNA抗体、C_4、ESR和CRP无相关性。结论:LN患者血清维生素D水平低于普通人群,低水平维生素D主要与SLE的肾损害有关,但并非LN发病的决定性因素,仅在一定程度上影响蛋白尿及补体C_3水平。

Objective：To explore the expression level and significance of 25（OH）D in peripheral blood of patients with lupus nephritis（LN）.Methods：Systemic lupus erythematosus（SLE） patients were divided into two groups according to with or without LN.The clinical and laboratory data of SLE patients were collected.The health examiners were selected as the control group.The serum levels of 25（OH）D were measured in the three groups,and the relationship between the level of serum 25（OH）D and the clinical and laboratory indexes of LN patients was analyzed.Results：The level of 25（OH）D of SLE patients with or without LN was lower than the control group（P〈0.01）.The level of serum 25（OH）D of LN patients was negatively correlated with 24 hours urine protein quantitative,and was positively related to C3,and there was no correlation with SLEDAI score,anti ds DNA antibody,C4,ESR and CRP.Conclusion：The serum vitamin D levels in patients with LN were lower than the general population.Low level vitamin D was mainly associated with renal damage of SLE,but it was not a decisive factor in the incidence of LN.It only affected albuminuria and complement C3 level to a certain extent.