摘要
线粒体自噬是一种选择性自噬,是指细胞通过自噬的机制选择性地清除线粒体的过程。线粒体自噬在清除功能失调的线粒体、降低线粒体数量及维持细胞稳态中起着重要的作用。它的分子机制涉及PINK1/Parkin、BNIP3、NIX和FUNDC1等多种蛋白。线粒体发生功能障碍或损坏都可能造成严重的后果,甚至导致细胞死亡。研究发现线粒体自噬紊乱与多种眼科疾病的发生有关,如白内障、青光眼、年龄相关性黄斑变性(age-related macular degenration,AMD)、糖尿病视网膜病变(diabetic retinopathy,DR)等。本文就线粒体自噬的发生机制和它在眼科相关疾病中的研究进行综述。
Mitophagy is a selective autophagy refers to theautophagy process by which cells selectively remove mitochondria. Mitophagy plays important roles in clearing up dysfunctional mitochondria, reducing mitochondrial numbers and maintaining cell homeostasis. Its molecular mechanisms involve several proteins such as PINK1/ Parkin, BNIP3, NIX, and FUNDC1. Mitochondrialdysfunction or damage may cause serious consequences, and may even lead to cell death. Studies have shown that disfunction of mitophagy is related to many eye diseases, for instance,cataract, glaucoma,age - related macular degeneration, diabetic retinopathy, etc. This review deals with the mechanisms of mitophagy and its research on ocular diseases.
出处
《国际眼科杂志》
CAS
北大核心
2018年第3期478-481,共4页
International Eye Science
